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Webinar

When the Sample Waits: Pre-Analytical Variability in Multi-Analyte Blood Testing

Join Today's Clinical Lab and Streck for a discussion on how blood collection and handling conditions influence sample integrity and the accuracy of downstream molecular and biomarker analyses.

Written byToday's Clinical Lab

LIVE WEBINAR: September 23rd, 2026, 1:00pm ET


EDTA remains an effective anticoagulant when blood can be processed promptly, but many real-world workflows impose practical limitations. Batching, transport, staffing gaps, remote-site collection all introduce delay. During that window, the sample continues to change. Cells can break down and release material into plasma that was never present at the moment of collection, making the biological signal harder to interpret. This webinar examines what happens in a tube of blood after draw, why the composition at draw time is the reference point that matters, and how pre-analytical conditions shape results across multi-analyte workflows.

The discussion will begin with cell-free DNA, where white blood cell stability is critical in limiting genomic DNA background, then extend to more delay-sensitive analytes including cell-free RNA, extracellular vesicles, and select protein markers. Attendees will learn how to recognize when variability may reflect collection or handling artifact rather than true biology and what to specify up front when designing a pre-analytical protocol.

Learning Objectives

  • Describe what changes in a blood sample between draw and processing, and why composition at the moment of draw is the reference point.
  • Explain why stabilizing the cellular fraction protects cell-free DNA results, and why analytes measured alongside it can be more sensitive to delay.
  • Recognize when variability in a data set is more likely to reflect a collection or handling artifact than a biological finding.
  • Specify and document the pre-analytical conditions a multi-analyte workflow requires before a protocol is locked.

Featured Speaker

      Jing Li


Jing Li received a Ph.D. in Pharmaceutical Sciences from Wayne State University and completed postdoctoral training at the University of Nebraska Medical Center. For the past 7 years, Jing has worked in Streck’s Research and Development department focusing on the development of new stabilization technologies intended for liquid biopsy applications.


Sponsor

  • Streck logo