Type 2 Diabetes Now One of the Top Five Most Studied Diseases Globally, Finds New Analysis
Increase in T2D research comes at time of rising interest in GLP-1s, including Ozempic and Wegovy
Boston, US. July 11, 2024 — Phesi, a leading clinical development analytics company, has today published the results of its mid-year analysis of clinical trials conducted globally in the first six months of 2024. The analysis of 66,935 clinical trials reveals that COVID-19 is no longer in the top five most studied indications, replaced by type 2 diabetes (Fig. 1).
The top five most studied diseases are now breast cancer, solid tumor, stroke, prostate cancer, and type 2 diabetes. With growing interest in GLP-1s to treat other conditions, including obesity, there has been clear additional investment in this area. At the same time, oncology remains an area of high investment, with three of the top five most studied diseases being in oncology.
“Following the success of therapies like Ozempic, it’s no surprise that type 2 diabetes research is being prioritized by biopharmaceutical companies. But with complex conditions with several comorbidities—like type 2 diabetes—sponsors looking to keep costs low and minimize protocol amendments will need to design protocols with higher degrees of precision. This starts by building a granular, comprehensive profile of the target patient,” said Dr. Gen Li, president and founder, Phesi. “This will be vital in turning the tide on increasing Phase 2 cancellation rates across all indications. The concern is that the almost a third of trials canceled at Phase 2 is becoming the new normal—driving up costs across the industry and delaying therapies from getting to market.”
The recent analysis is the latest of Phesi’s annual and half-yearly reports on the state of global clinical development. Phesi’s team analyzed data from its Trial Accelerator™ platform, which contains data from more than 120 million patients in more than 400,000 cohorts. This most recent analysis found that the rise in Phase 2 study attrition first identified in 2022 continues (Fig. 2). So far in 2024, 32 percent of trials were terminated during Phase 2—a 56 percent increase on pre-pandemic levels. High levels of cancellations at Phase 2 not only increase the costs of clinical development but also have a knock-on effect on the rate at which new therapies reach patients.
“In the last two decades, medical advances have driven a shift toward precision medicine. Yet clinical development practices have struggled to adapt to more specific patient inclusion criteria and smaller patient pools. Trial design requires huge volumes of data to ensure participant selection matches the level of precision in the medicines being tested,” said Dr. Li. “Other complicating factors include the high number of investigators backing out from clinical trials post COVID-19, and new diversity requirements from regulators—including the FDA—which exacerbate enrollment difficulties.
“The clinical development industry can turn the tide on rising attrition by beginning with the patient. By leveraging predictive analytics, sponsors can design protocols better aligned with the target patient population, and identify the best performing investigator sites with a higher level of precision.”
The full analysis can be found in the published report.