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The study demonstrates the feasibility of testing novel immunotherapy combinations in patients with operable pancreatic cancers via platform clinical trials.
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Treatment-Trio Shows Promise in Patients with Pancreatic Cancers

Combination therapy improved median disease-free and overall survival in pancreatic ductal adenocarcinoma cases

John Hopkins Medicine
Published:Jul 18, 2023
|2 min read
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Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine (GVAX), the immune checkpoint therapy (nivolumab), and an anti-CD137 agonist antibody treatment (urelumab) is safe. It appears effective when given two weeks prior to cancer-removal surgery and increases the amount of cancer-killing T cells in the tumors, according to new research by Johns Hopkins investigators that was published recently in Nature Communications.

This study—led by researchers at the Johns Hopkins Kimmel Cancer Center, the Bloomberg~Kimmel Institute for Cancer Immunotherapy, and the Johns Hopkins University School of Medicine—is the latest from an ongoing platform trial formed in 2015 to study immunotherapy treatments before surgery (neoadjuvant) and after surgery (adjuvant) for patients with pancreatic cancer. This format enables researchers to use data generated by the trial to advance the development of immunotherapies for pancreatic cancer within the same study.

In this most recent part of the trial, 10 participants received the combination treatment. The median disease-free survival was 33.51 months, and the median overall survival (time to death) was 35.5 months. These were higher than found in previous arms of the trial that tested the pancreatic cancer vaccine alone and in combination with nivolumab, but because of the small number of patients, the results did not have statistical significance.

The tumor specimens studied in the recent arm also had much higher amounts of cancer-killing immune cells than specimens from patients given only the vaccine or the vaccine plus nivolumab.

The results suggest that this therapy combination warrants further study in a larger clinical trial, says senior study author Lei Zheng, MD, PhD, co-director of the Pancreatic Cancer Precision Medicine Center of Excellence and professor of oncology at the Johns Hopkins University School of Medicine.

The platform trial has two purposes regarding pancreatic cancer treatments given during the two-week “window of opportunity” prior to surgery, adds Zheng. First, it allows the immunotherapies to teach the patient’s immune cells how to respond to tumors, so they can continue surveillance later if the cancer recurs. Second, by evaluating the tumors removed during surgery, it enables investigators to see how well the tumors respond to the treatment. A fourth arm of the trial, studying anti-interleukin-8 neutrophil-blocking antibodies in pancreatic tumors, is ongoing.

- This press release was originally published on the John Hopkins Medicine website