Transposable Elements Causing Rare MSL3 Syndrome Identified

A new family of DNA elements that control the activation of certain genes known to cause a rare disease known as MSL3 syndrome in children has been identified. The study led by researchers at the Queen Mary University of London and published recently in Nature Structural & Molecular Biology shines new light on the mechanism behind this poorly understood disease, hoping that it can lead to better treatments for this and similar conditions in the future. 

Mutations in the MSL3 gene are known to cause a rare disease in children called MSL3 syndrome—a newly discovered disease with only around 50 registered diagnoses worldwide, although scientists predict that more cases are currently undiagnosed. 

It is a disease that is in desperate need of attention. The mechanism through which MSL3 mutations lead to this syndrome is not known. There is only one previous study that discovered this disease gene, but it is not clear why mutations in MSL3 cause this disorder. 

The researchers identified that a family of transposons, known as long interspersed nuclear elements (LINE-1), could function as a switch to turn on certain genes. Researchers previously thought that the MSL3 complex regulates genes directly, but this research shows that the complex does so via activating these transposable elements. 

Mutations in the MSL3 gene can lead to perturbation of genes involved in development. The developmental genes are intact, but the program that determines how the genetic information will be fine-tuned is impaired. This could lead to a global delay in the development of multiple organs, including the brain.

“Although these DNA elements are popularly known as jumping genes, most are immobile and not harmful. We only know the tip of the iceberg about how host species are using this virus-like DNA to our own advantage,” says lead author Pradeepa Madapura, PhD, associate professor at the Queen Mary University of London. 

Although this work provides novel insights into how MSL functions to regulate our genome, further research is needed to test whether drugs that alter this epigenetic pathway alleviate symptoms in children with mutations in their MSL genes. However, many epigenetic drugs that target this pathway are already in clinical trials for cancer therapy. 

- This press release was originally published on the Queen Mary University of London website