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As the demand for precision oncology continues to grow, these models will remain at the forefront of efforts to understand cancer complexity, personalize therapy, and ultimately improve patient outcomes.

Capturing Tumor Complexity and Diversity with Organoid and Patient-Derived Xenograft Models

John Gu, MBA

Patient-derived xenograft systems serve as an essential approach for studying tumor progression, treatment response, and resistance over time

Wenbo Xu (center) is a Stony Brook University PhD student studying triple-negative breast cancer in the Spector lab at Cold Spring Harbor Laboratory.

A New 'Link' to Triple-Negative Breast Cancer

Cold Spring Harbor Laboratory

New findings highlight the importance of non-coding RNAs in triple-negative breast cancer

Illustration and abstract photo of the gloved hands of a clinical researcher pipetting and culturing cells derived from patients to create patient-derived xenograft models.

Capturing the Complexity of Real Cancer Cases with Patient-Derived Xenograft Models

Michael J. Wick, PhD

Patient-derived xenograft models enable researchers to explore novel therapies and diagnostic tools within the context of specific mutational signatures, treatment histories, and more

Microscope image of 3D organoids cultured from esophageal cancer.

Unlocking the Potential of Patient-Derived Organoids for Personalized Sarcoma Treatment

UCLA Health

By using 3D mini tumor models that closely resemble a patient's tumor, treatments could be tailored more effectively, paving the way for more personalized cancer treatments

A vector illustration of clinicians, holding a magnifying lens and a syringe, examining the human kidneys with a bottle of drugs, tablets, and test tubes in the background.

Organoids Help Uncover the Genetics of Kidney Disease

National Institutes of Health

Innovative disease modeling and gene editing techniques begin to answer long-standing questions

Human brain samples preserved in plastic slides.

World’s First Brain Biobank Accelerates Clinical Research

Swathi Kodaikal, MSc

The CNIO network aims to use patient-derived samples to drive ethical, efficient, and high-precision clinical care

3D illustration of tumor cells

Location May Influence Tumor Cell’s Identity and Role in Cancer Biology

National Institutes of Health

New approach could provide insights into cancer progression, treatment response, and precise therapies

3D rendering of various common human organoids Tissue

Novel High Transmissibility Mechanism of Omicron Variant Revealed

The University of Hong Kong

First-ever, stable human organoid culture system from lung and nasal tissue helped study SARS-CoV-2 variant transmission

A Synapse Is Born: Human Brain Organoids Integrate with Mouse Cortex

A Synapse Is Born: Human Brain Organoids Integrate with Mouse Cortex

Swathi Kodaikal, MSc

Multimodal experiments with organoids may provide deeper insights into the human brain

Illustration of an artificial intelligence algorithm integrating data from organ-on-a-chip models.

Integrated BioAI Platforms Address Drug Development Bottlenecks

Isaac Bentwich, MD

From artificial intelligence to patients-on-chip, new technologies decrease reliance on animal testing