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Next Generation Sequencing (NGS)

Next Generation Sequencing (NGS)

The study modeled the use of mNGS testing that detects both RNA and DNA pathogens within a 48-hour turnaround time compared to conventional clinical workups.

Earlier Use of Metagenomic Sequencing May Streamline Meningitis, Encephalitis Workups

Delve Bio

Modeling data suggests early metagenomic sequencing could reduce unnecessary testing and shorten time to diagnosis for CNS infections

Pangenomics, a subset of bioinformatics, is the study of many different genomes from one specific species.

Compressive Pangenomics Breakthrough Enables Analysis of Millions of Genomes

University of California - San Diego

UC engineers introduce PanMAN, a data structure that compresses and encodes large-scale genomic variation and evolutionary history, transforming microbial and human genome studies

The left panel depicts a potential-like landscape, where white streamlines represent the inferred trajectory of cell states across time. Although single-cell RNA sequencing captures only static snapshots of cells, ddHodge reconstructs the patch-worked dynamical structure by connecting many local “nows” into a coherent global picture. The right panel shows a graph-based representation of high-dimensional cell states, on which local geometry is preserved to quantify key dynamical properties such as stability, divergence, and rotational components.

A New Way to Map How Cells Choose Their Fate

Kyushu University

Researchers present an innovative computational method based on modern mathematics to shed light on cell state dynamics and development

The researchers uncovered three vulnerabilities in the Oxford Nanopore MinION portable sequencer and its associated software.

Study Reveals Major Security Flaws in Portable DNA Sequencers

University of Florida

UF researchers find unreported security gaps in Oxford Nanopore’s portable sequencers

This milestone not only sets a GUINNESS WORLD RECORDS™ for the fastest human whole genome sequencing to date but represents a significant clinical development that would expedite more precise treatments to critically ill babies in the NICU.

Record-Breaking Human Whole Genome Sequencing Accelerates Genomic Diagnostics in Neonatal Intensive Care

Boston Children's Hospital

Current rapid genomic sequencing takes days, but critical NICU decisions often can't wait hours

Closing the Diagnostic Gap in CNS Infections

Delve Bio

Metagenomic next-generation sequencing helps clinical labs diagnose meningitis and encephalitis faster, supporting timely and informed treatment decisions

NGS-based assays are now considered standard for optimal treatment planning in many tumor types.

Rapid In-House NGS Is Closing the Gap in Precision Cancer Therapy

Luca Quagliata, PhD, BCMAS, COA

Automated NGS reduces complexity and cost, enabling community hospitals to expand testing without major infrastructure investments

In 2022, 2.3 million women were diagnosed with breast cancer worldwide and there were 670,000 related deaths.

15,000 Women a Year with Breast Cancer Could Benefit from Whole Genome Sequencing, Say Researchers

University of Cambridge

Despite significant progress in recent years, it remains challenging to accurately identify the best treatments for individual patients and to predict cases with poorer prognosis