Genomics News, Articles | Today's Clinical Lab

While histologic examination and immunohistochemistry remain the foundation of cancer diagnosis, the authors explain that molecular profiling can provide critical additional insight when conventional approaches fall short.

CAP Highlights Molecular Testing to Clarify Difficult-to-Classify Tumors

College of American Pathologists

CAP authors outline how genomic, transcriptomic, and epigenetic profiling can support pathologists when conventional histology and immunohistochemistry fall short, particularly in cancers of unknown primary

The study modeled the use of mNGS testing that detects both RNA and DNA pathogens within a 48-hour turnaround time compared to conventional clinical workups.

Earlier Use of Metagenomic Sequencing May Streamline Meningitis, Encephalitis Workups

Delve Bio

Modeling data suggests early metagenomic sequencing could reduce unnecessary testing and shorten time to diagnosis for CNS infections

Type 2 diabetes (T2D) is a growing health concern in sub-Saharan Africa, but it is often underdiagnosed or misdiagnosed.

Mapping Proteins in African Genomes Reveals New Paths to Fight Type 2 Diabetes

Helmholtz Zentrum München

The research could help develop representative biomarkers and treatment strategies—bringing more precise and effective health care to millions of people

Pangenomics, a subset of bioinformatics, is the study of many different genomes from one specific species.

Compressive Pangenomics Breakthrough Enables Analysis of Millions of Genomes

University of California - San Diego

UC engineers introduce PanMAN, a data structure that compresses and encodes large-scale genomic variation and evolutionary history, transforming microbial and human genome studies

Quagliata sat down with Today’s Clinical Lab at the Association for Molecular Pathology’s annual meeting in November.

Molecular Pathology Will Lean Further into Liquid Biopsy and Proteomics in 2026

Scott Wallask, BA, Luca Quagliata, PhD, BCMAS, COA

Thermo Fisher’s Luca Quagliata also discusses pathologists’ desire for rapid turnaround times

The left panel depicts a potential-like landscape, where white streamlines represent the inferred trajectory of cell states across time. Although single-cell RNA sequencing captures only static snapshots of cells, ddHodge reconstructs the patch-worked dynamical structure by connecting many local “nows” into a coherent global picture. The right panel shows a graph-based representation of high-dimensional cell states, on which local geometry is preserved to quantify key dynamical properties such as stability, divergence, and rotational components.

A New Way to Map How Cells Choose Their Fate

Kyushu University

Researchers present an innovative computational method based on modern mathematics to shed light on cell state dynamics and development

This milestone not only sets a GUINNESS WORLD RECORDS™ for the fastest human whole genome sequencing to date but represents a significant clinical development that would expedite more precise treatments to critically ill babies in the NICU.

Record-Breaking Human Whole Genome Sequencing Accelerates Genomic Diagnostics in Neonatal Intensive Care

Boston Children's Hospital

Current rapid genomic sequencing takes days, but critical NICU decisions often can't wait hours

In 2022, 2.3 million women were diagnosed with breast cancer worldwide and there were 670,000 related deaths.

15,000 Women a Year with Breast Cancer Could Benefit from Whole Genome Sequencing, Say Researchers

University of Cambridge

Despite significant progress in recent years, it remains challenging to accurately identify the best treatments for individual patients and to predict cases with poorer prognosis