TEQUILA-seq Solves Long-Read RNA Sequencing Woes
Children's Hospital of Philadelphia
Easy-to-implement technology reduces the per-reaction cost of target capture by two to three orders of magnitude as compared to commercial solutions
Genetic Engineering
CRISPR-Cas9-Based Tool May Help Slow Antimicrobial Resistance Spread
University of Exeter
Researchers apply CRISPR-Cas9 editing to bacterial plasmids, exploit bacteria’s immune system
Novel, High-Throughput Method for Screening Protein-Secreting Microbes
Tokyo Institute of Technology
Simple approach combines biosensors and microfluidics to screen large-scale libraries for industrially useful bacteria
Structure and Function of Newly Discovered CRISPR Immune System
Utah State University
In tandem papers in Nature, researchers report effects of Cas12a2
FDA Approves First Gene Therapy to Treat Adults with Hemophilia B
U.S. Food and Drug Administration
The one-time gene therapy, Hemgenix, was evaluated in two studies and was found to decrease annualized bleeding rate
NIH Researchers Home In on a New Cause of Stargardt Disease
National Institutes of Health
Study may help lead to gene therapy for rare inherited blinding disease
New CRISPR-Cas Approach Permits More Precise DNA Cleavage
Massachusetts General Hospital
So-called SpRYgests enable DNA cutting at practically any sequence for DNA editing
Discovery Broadens Scope of Use of CRISPR Gene Editing
Northwestern University
Combining two powerful therapeutic technologies may change the landscape of medical therapeutics
Researchers Discover Dozens of Genetic Defects Important for Immune Defense
University of Helsinki
Results suggest that targeted inhibition of certain NFKB signaling pathway components is an viable therapeutic approach
How CRISPR-Cas9 Contributed to Rare Disease Research in 2021
Brydie Thomas-Moore, PhD
Research from this past year highlights the potential of CRISPR-Cas9 technology in modeling and treating rare disease