Drug Targets

Water purity can drastically impact quality control during drug discovery, validation, and characterization  

The hit-to-lead and lead optimization stages of novel therapeutic characterization require sensitive, water-dependent experiments 

Findings point to the potential for using existing cancer therapies to treat drug-resistant epilepsy

Carolyn R. Bertozzi, PhD, is credited for inventing biorthogonal chemistry and “copper-free click chemistry”

Study identifies blood proteins that indicate which patients with iMCD are most likely to benefit from siltuximab

Nanobody-based tool may help researchers design drugs to target “undruggable” proteins involved in chronic diseases

Super-enhancers are a major contributor to pancreatic ductal adenocarcinoma progression  

Researchers report that levels of a single molecule predict whether a patient has subtype 1 or subtype 2 of the disease

Case Western Reserve researchers uncover novel drug targets by piecing together receptor structures