Car T News, Articles | Today's Clinical Lab

A growing number of T cell therapies, including CAR-T interventions are personalized treatments that genetically modify a patient's T cells to target and destroy cancer cells.

Epigenetic Reprogramming Safely Modifies Multiple Genes in T Cells Simultaneously for CAR-T Therapies

Arc Institute

Epigenetic editors create enhanced T cells that show improved survival in cancer models, without the risk of DNA damage

Illustration of two CAR T-cells attacking a cancer cell.

Researchers Move Toward Off-the-Shelf CAR T-Cell Therapy for Cancer

Today's Clinical Lab

New breakthrough from Memorial Sloan Kettering Cancer Center shows how off-the-shelf CAR T cells from healthy donors can be modified to fight cancer without immune rejection

3D illustration of brain tumor being attacked by immune cells against a background of a human brain in a head X-ray image.

IL-13Rα2-Targeting CAR T-Cell Therapy Improves Brain Cancer

City of Hope

Researchers were able to deliver the CAR-T cells directly into the tumor site and the cerebrospinal fluid

A vector illustration of storing umbilical cord blood cells.

Cord Blood-Derived CAR NK-Cell Therapy Safe for B-Cell Malignancies

University of Texas MD Anderson Cancer Center

Researchers identified characteristics of donated cord blood units associated with strong clinical responses in the Phase 1/2 trial

Graphical illustration of a cancer cell being attacked by T cells.

Bioengineering CAR-T Cells with IL-10 for Robust Therapies

Ecole Polytechnique Fédérale De Lausanne

New research introduces CAR-T cells that flourish in tumor environments, greatly advancing cancer immunotherapies

3D illustration of a B cell and antibodies in close-up.

Bendamustine Treatment before CAR T-Cell Therapy May Be Detrimental

Vall d'Hebron Institute of Oncology

CAR T-cell therapy recipients with refractory lymphoma showed poorer treatment outcomes when treated with bendamustine

A T cell attacks a cancer cell by binding to specific receptors on the cell surface.

Protein “Barcodes” Can Precisely Guide CAR T Cells to Targets

Children's Hospital of Philadelphia

Identifying peptide backbones that link protein complexes to cancer cells can help maximize CAR therapy applicability to different tumor types

3D illustration of T cells attacking a cancer cell.

CAR T-Cell Therapy Shows Race-Agnostic Response in MM Patients

American Society of Hematology

Multiple myeloma patients treated with CAR T-cell therapy showed similar survival outcomes regardless of race or ethnicity

Two researchers wearing hair nets, masks, gloves, and white lab coats examine microscope and liquid filled beakers in a laboratory. Printed DNA strands run across right side of the image.

Cell and Gene Therapies Demand a Robust System

Miltenyi Biotec

Standardizing your CGT platform to ensure consistency during experiments is essential for improving future clinical outcomes

An unhappy mature gray-haired man suffering from muscle pain near his elbow while sitting on a sofa during the day.

Modified CAR-T Therapy Abates Myasthenia Gravis Symptoms

National Institutes of Health

Trial showed that mRNA-led CAR-T therapy may be a safe and durable treatment option for this rare disease

CAR-T