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White Paper

Library preparation is the first step for accurate next-generation sequencing (NGS) and entails a labor-intensive procedure to convert DNA samples into a format suitable for sequencing. 


The process of adding adapters and amplifying them to generate a library of fragments ensures that the genetic material is ready for analysis. The quality and accuracy of library preparation directly impact the reliability and depth of insights gained from sequencing data, making them a fundamental aspect of any genomic study. 

Implementing automation replaces the laborious tasks associated with manual library prep, allowing scientists to focus on analyses and data interpretation. This shift not only saves time but also ensures greater accuracy and reproducibility of research findings.

By using automated library preparation, laboratorians can expect notable enhancements in their workflow. From post-shear clean-up to elution, every step is handled by advanced technology, resulting in libraries that are comparable in quality to manually prepared ones. 

This white paper highlights:

  • How MIRO CANVAS automates PacBio SMRTbell whole genome sequencing library preparation

  • The benefits of PCR-free long-read sequencing and streamlined protocols

  • Comparative analysis between manual and MIRO CANVAS-prepared libraries

  • Real-world applications and implications for genetic research