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Pancreas cancer harbors cells in different states, with classical cells (red) and basal cells (turquoise) co-existing within individual tumors. Basal cells, which typically are associated with aggressive disease, show increased sensitivity to KRAS inhibitors, a promising new drug class for pancreatic cancer.
|3 min read

New Research Suggests How to Improve Effectiveness of KRAS Inhibitors in Pancreatic Cancer

New research in mouse models has uncovered a new mechanism of resistance to KRAS inhibitors
byMemorial Sloan Kettering Cancer Center
Epigenetic therapies are a new class of drugs that focus on modifying the activity of genes without changing the underlying DNA sequence.
|2 min read

Epigenetic Combo Therapy Shows Promise Against Rare Sarcomas

The team’s next step is to introduce immunotherapy to treat soft tissue sarcomas
byMemorial Sloan Kettering Cancer Center
A clinician holds a syringe and a vaccine vial, each in a gloved hand.
|2 min read

New KRAS-Targeting Cancer Vaccine Safe, Immunogenic in Trials

Off-the-shelf vaccines are as efficacious as mRNA vaccines and are cheaper to produce and administer
byMemorial Sloan Kettering Cancer Center
3D illustration of chromosomes.
|5 min read

Can Chromosomal Instability Drive Epigenetic Alterations in Cancer Cells?

Sequestration of chromosomes into micronuclei disrupts the organization of chromatin and triggers epigenetic dysregulation
byMemorial Sloan Kettering Cancer Center
A medical procedure referral form
|5 min read

Study Identifies Biomarker That May Help Predict Benefits of Immunotherapy

The findings pave the way for prospective clinical trials designed to test whether this biomarker can improve outcomes
byMemorial Sloan Kettering Cancer Center
Illustration of cancer cells
|3 min read

Learning How Cancer Cells Evade Immune Defenses Inspires New Treatment Approach

The results help explain why some tumors do not respond to immunotherapy and suggest ways to improve it
byMemorial Sloan Kettering Cancer Center
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