Toxicology laboratories need to rapidly screen for the presence of an increasing number of designer and illicit drugs in biological samples, quantitatively confirm compounds, and have access to retrospective analytical data. An all-in-one workflow that combines efficient liquid chromatography (LC) with high-resolution, accurate-mass (HRAM) mass spectrometry enables detection and quantitation of a large panel of analytes in a single automated run, providing a fast turn-around time for confident results.
This workflow can be achieved with the Thermo Scientific™ Tox Explorer™ Collection, which ensures a robust, reliable, sensitive, and easy-to-implement workflow for toxicology laboratories. The method leverages the power of Thermo Scientific™ Orbitrap™ high-resolution, accurate-mass technology to perform accurate targeted screening and quantitation with high efficiency, reliability, and confidence. This tech note demonstrates how such a LC-HRAM-based quantitation and screening approach was used to obtain high data quality for testing use of illicit drugs in urine.