Today's Clinical Lab - News, Editorial and Products for the Clinical Laboratory
Female doctor asks questions about cancer patient
iStock, Kanizphoto

How Perception of Risks and Benefits Influence Cancer Clinical Trial Withdrawal

Clinical trial retention increase when perceived benefits are greater than burdens

University of Pennsylvania School of Nursing

Penn Nursing is the number one nursing school in the world , and has multiple number one and top-rated master’s programs here in the U.S. Join the ranks of Penn Nursing experts and leaders who have been advancing science and delivering solutions, shaping policy and practice, and engaging communities to promote health for over a century. These will be your collaborators, your mentors, your friends, leading to a healthier future.

ViewFull Profile
Learn about ourEditorial Policies.
Published:Dec 08, 2022
|2 min read
Register for free to listen to this article
Listen with Speechify

While people with cancer have options to participate in cancer clinical trials (CCTs), it can be challenging when they encounter difficulties enrolling and remaining in the trial. Trial withdrawal, although every participant’s right, can thwart study goals and hamper advancing novel treatments.

Until now, little attention has focused on what influences retention after participants are enrolled in the trial, especially the role of perceived benefits and burdens. A new investigation from the University of Pennsylvania School of Nursing (Penn Nursing) has examined the association between patients’ perceived benefits and burdens of research participation and CCT retention. It found that patients perceived important benefits from CCT participation, which was associated with trial retention, even among those who also perceived substantial burdens.

“The findings of how perceptions of benefits and burdens were associated with CCT withdrawal outcomes provide novel and foundational evidence of the importance of understanding these perceptions for trial retention,” explains Connie M. Ulrich, PhD, RN, FAAN, Lillian S. Brunner Chair in Medical and Surgical Nursing, Professor of Nursing and Professor of Medical Ethics and Health Policy at Penn Nursing. Ulrich is the lead investigator of the study.

The study found that when perceived benefits were equal to or greater than perceived burdens, participants were less likely to withdraw than those who perceived the burdens to be greater than the benefits. How participants think about benefits and burdens in a research trial may differ from how researchers and IRBs discern the trial’s acceptability.

“Protection of human participants is critical, but more research is needed on how participants perceive benefits, the different types and categories of benefits, and implications of perceived benefits for retention to elucidate the role of benefits compared with the risks and burdens that participants are asked to bear,” says Ulrich.

- This press release was originally published on the University of Pennsylvania School of Nursing website