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A clinician holds a vial of human papillomavirus or HPV vaccine.
A viral infection usually clears up on its own, but some HPV types can give rise to different kinds of cancer after many years.
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Gender-Neutral Vaccination Prevents Oncogenic HPV Most Effectively

Vaccinating boys and girls induces herd immunity that helps eradicate oncogenic HPV types more quickly

Karolinska Institutet
Published:Nov 09, 2023
|2 min read
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The human papillomavirus (HPV) comprises over 200 virus types. A viral infection usually clears up on its own, but some HPV types can eventually, after many years, give rise to different kinds of cancer, of which cervical cancer is the most common. The HPV vaccine has been around since 2006. Initially, it was given exclusively to girls around the age of 12, but since August 2020, the HPV vaccine has been offered to both boys and girls in the year-five general vaccination program.

Karolinska Institutet researchers behind the present study, published recently in Cell, Host & Microbe, have looked at how the composition of HPV types changes over time in postvaccination populations. They studied this in 33 different towns in Finland, which were randomly assigned to vaccinate boys and girls, to vaccinate girls only, or to offer no vaccination.

The study included children born between 1992 and 1994 who were followed up at the age of 18 (over 11,000 individuals) and 22 (over 5,500 individuals), representing four and eight years after vaccination. The vaccine used then protected against HPV types 16 and 18, which cause 70 percent of all HPV-related cervical cancers, but also transpired to provide cross-protection against types 31 and 45. The vaccine coverage rate was up to 50 percent.

“The fact that the HPV vaccine study randomized the communities to different treatment programs is what enabled us to study the effects of vaccination,” says the study’s first author Ville Pimenoff, PhD, docent of evolutionary medicine at the Department of Clinical Science, Intervention and Technology, Karolinska Institutet.

The results show that eight years after vaccination, the prevalence of HPV types 16 and 18 declined significantly in the 22 towns in which the vaccine was provided. In the eleven towns that only vaccinated girls, there was a decrease in HPV 31 cases, while in the eleven towns that vaccinated girls and boys, there was a clear decline in both HPV 31 and 45 cases.

“This shows that you get stronger herd immunity if you vaccinate both boys and girls,” says Pimenoff. “According to our calculations, it would take 20 years of vaccinating girls to achieve the same effect that can be achieved in eight years with a relatively moderate vaccination coverage rate of gender-neutral vaccination.”

The researchers are also able to show that the virus types eliminated by the vaccine were replaced by other, less oncogenic HPV types, which was considered a moot but has been proven a fact now. The risk of cancer from the virus types against which the vaccine protects is negated, however, the risk of cancer per se is not eliminated as they are replaced by low-risk virus types.

“The HPV vaccine is effective against the high oncogenic HPV types and studies, including our own, show that there is no reason to be concerned about the observed increase of low oncogenic HPV types since they very rarely cause cancer,” Pimenoff continues.

A vaccine is also now used that targets nine different virus types, including some of those that were observed to increase in the current study. The changes in virus type composition also have consequences for the cervical screening that runs parallel to the vaccinations. Here the search is for high-risk HPVs, such as 16 and 18. “But as more and more vaccinated women reach screening age, we’ll have to start testing them at another frequency or stop altogether,” says Pimenoff.

- This press release was originally published on the Karolinska Institutet website