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Graphical illustration of a female reproductive system with cancerous growth on the endometrial lining of the uterus.
As endometrial cancer is hormone-dependent, estrogens can play a role in its development and progression.

Endocrine Disruptors May Elevate Endometrial Cancer Risk

Serum xenoestrogen burden negatively impacts women’s health and may contribute to cancer progression

Universidad de Granada

The  University of Granada  was founded in 1531, continuing a long teaching tradition that links with that of the Madrasa of the last Nasrid Kingdom. More than 60,000 undergraduate and postgraduate students study  at the  UGR and another 10,000 take complementary courses ,  language courses ,  summer courses , etc. 3,500 teachers teach and more than 2,000 administrative, technical and service personnel work.

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Published:Mar 13, 2024
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Research carried out by the Universidad de Granada (UGR), Instituto de Investigación Biomédica de Bellvitge (IDIBELL), the Catalan Institute of Oncology and the Biohealth Research Institute in Granada (ibs.GRANADA), published in Environmental Health Perspectives, has revealed a link between environmental pollutants and endometrial cancer. The collaborative study involved scientists and doctors from Bellvitge University Hospital and the Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP).

Endometrial cancer is a type of tumor that develops on the inner lining of the uterus. It accounts for more than 5,000 new cases of cancer in Spain each year and has a major impact on women’s health. The incidence of this type of cancer is increasing, partly due to population aging. As endometrial cancer is hormone-dependent, estrogens can play a role in its development and progression.

Effect of endocrine disruptors on hormone function

The study examined the relationship between endometrial cancer and exposure to mixtures of environmental pollutants that can disrupt hormone function. This class of chemicals, also known as endocrine disruptors, act as xenoestrogens and are found in many industrial products, including pesticides and herbicides, as well as in cosmetics and other everyday consumer products.

Using advanced chemical analysis techniques and biological testing, the researchers assessed the total hormonal burden in the blood samples from more than 300 women with and without endometrial cancer. “The use of these biological tests helps us understand the negative impact of chemical mixtures,” explains Marieta Fernández, PhD, a UGR professor and researcher at the ibs.GRANADA and CIBERESP.

The results show a link between exposure to endocrine disruptors and an increased risk of developing endometrial cancer. “Interestingly, we saw the effect with moderate doses of xenoestrogens, but not with high doses, similar to what was observed with endogenous hormones,” adds Laura Costas, PhD, a researcher at IDIBELL and the Catalan Institute of Oncology.

“Since this is a hormone-dependent cancer, this relationship is probably linked to the nature of the tumor itself. Therefore, we also want to study whether the presence of xenoestrogens leads to a worse pathological evolution in women who already have the disease,” says Costas.

The research sheds light on the negative impact of endocrine disruptors on human health and has significant implications for public health. It also highlights the need to consider the combined effects of chemical mixtures when assessing environmental risk.

- This press release was originally published on the Universidad de Granada website