Health care professional administering a COVID-19 vaccine to a child

COVID-19 Vaccine for Children after MIS-C Appears Safe

NIH-supported study finds no serious complications following rare immune condition

National Institutes of Health
Published:Jan 04, 2023
|3 min read

A study of children and adolescents who received a COVID-19 vaccination following multisystem inflammatory syndrome (MIS-C) found that there were no reports of serious complications including myocarditis or MIS-C reoccurrence. About half of participants experienced mild and typical reactions, including arm soreness and fatigue. The study, funded by the National Institutes of Health, demonstrates that it is safe to get a vaccine after having MIS-C. The findings are published in JAMA Network Open.

The multicenter, observational study, the largest of its kind to examine COVID-19 vaccination in this group, helps resolve a lingering question about whether the COVID-19 vaccine can increase the risk of health problems in young people who have had MIS-C, a rare and potentially fatal immunological reaction that can occur following infection with SARS-CoV-2, the virus that causes COVID-19. 

MIS-C is a poorly understood condition that affects one in about 3,000 to 4,000 children and adolescents who had COVID-19, according to the Centers for Disease Control and Prevention (CDC). It occurs a few weeks after COVID-19 infection and can lead to organ failure. Symptoms can range from stomach pain, fever, and rash to inflammation of the heart muscle, a serious condition called myocarditis. The exact causes of MIS-C are unknown, but medications can be given to decrease the inflammation that can damage organs.

Some families and health care professionals have questioned whether COVID-19 vaccines could lead to more serious adverse reactions in those with a history of MIS-C, including a recurrence of the disease, but data on this topic were lacking.

The cross-sectional study included 22 medical centers (21 in the United States and one in Canada) participating in the NHLBI’s Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children (MUSIC) study. It enrolled 385 patients aged five years or older with prior MIS-C who were eligible for COVID-19 vaccination. Of this group,185 (48.1 percernt) received at least one vaccine dose. The median age was 12.2 years and 73.5 percent were male. The participants were racially diverse—24.3 percent were Black, 31.9 percent were Hispanic, and 28.6 percent were White. The median length of time from their MIS-C diagnosis to their first vaccine dose was nine months.

Of those who received a COVID-19 vaccination following MIS-C, mild adverse reactions—mostly arm soreness and fatigue—occurred in 49 percent of them, similar to the general population. There were no reports of serious complications, including myocarditis or recurrence of MIS-C, the researchers said.

“We are very reassured by the results and this safety data should be comforting to families and health care professionals when considering and recommending vaccination,” said study co-leader Matthew D. Elias, MD, a pediatric cardiologist at Children’s Hospital of Philadelphia and clinical assistant professor of pediatrics at the University of Pennsylvania, Philadelphia. Audrey Dionne, MD, a pediatric cardiologist at Boston Children’s Hospital and assistant professor of pediatrics at Harvard Medical School, Boston, also served as the study’s co-leader. The researchers have routinely treated children with MIS-C throughout the pandemic.

Dionne added that the findings provide support for the CDC’s recommendation that patients with a history of MIS-C receive a COVID-19 vaccine at least 90 days after diagnosis and that it is safe to do so.

“In light of the acute and long-term consequences of COVID-19 it is vital to continue the development, testing, and deployment of preventive as well as therapeutic agents in at-risk groups as well as the general population,” said Gary H. Gibbons, MD, director of the National Heart, Lung, and Blood Institute (NHLBI), part of NIH.

To date, more than 9,000 patients have been diagnosed with MIS-C in the United States, and 74 have died, according to data from the CDC. However, the disease appears to be on the decline, according to studies by others.

“A big part of that decline is that COVID vaccination has been protective against this rare condition in those who have received it,” Dionne said.

While many patients with MIS-C make a full clinical recovery, some studies suggest chronic symptoms linger after MIS-C, which is why long-term outcome studies will be beneficial, the researchers said. The MUSIC study is part of an NIH collaborative research effort called CARING for Children with COVID, which aims to better understand how COVID-19 affects children, who account for roughly 13 percent of the total cases in the United States.

- This press release was originally published on the National Institutes of Health website