When a central nervous system condition is suspected, clinical laboratories play a critical role in determining whether infection is present and, if so, identifying the causative pathogen. Even with extensive testing, many cases of meningitis and encephalitis remain undiagnosed. The absence of actionable results can delay treatment decisions, prolong hospital stays, and increase the risk of lasting complications and mortality.
Traditional diagnostic tools require knowledge of which pathogens to test for and have limitations in speed, sensitivity, and scope. Metagenomic next-generation sequencing (mNGS) offers a broader view. By simultaneously sequencing all of the genetic material present, mNGS provides comprehensive and efficient detection without prior assumptions.
This article examines how mNGS can expand diagnostic capabilities and discusses its increasing practicality for routine use, fueled by progress in automation and bioinformatics.
Download this article to learn:
The limitations of traditional diagnostic workflows and how they can be addressed
What each step of the mNGS process involves and how it enables comprehensive, unbiased pathogen detection
How advances in mNGS technology are shortening turnaround times and simplifying data interpretation
