Cell & Tissue Culture Articles | Today's Clinical Lab

Z-projection of cytoskeletal staining of invading cancer cells within the tumor-on-chip model (F-actin = green, DAPI = blue).

Improving Cancer Therapies with Organ-on-a-Chip Technologies

Jonathan Klane, MSEd, CIH, CSP, CHMM, CIT, Miriam Bergeret, MSc

Can modeling the complexities of disease using organ-on-a-chip platforms help improve cancer therapies?

Conceptual global crisis of COVID-19 virus particles amidst a crowd of people.

Infectious SARS-CoV-2 Found in Hospital Air

University of Montreal Hospital Research Centre

Unique sample collection and cell culture methods may help analyze the airborne transmission of viruses

Illustration of a female clinician pointing to a vector of a human pancreas.

Pancreatic Lesions May Occur Earlier than Previously Thought

American Association for Cancer Research

Researchers partnered with Gift Of Life Michigan to analyze healthy pancreata from deceased donors

A Synapse Is Born: Human Brain Organoids Integrate with Mouse Cortex

Swathi Kodaikal, MSc

Multimodal experiments with organoids may provide deeper insights into the human brain

Photo of a clinical lab professional in the lab holding a pipette while developing a cell therapy.

Tips for Transitioning Cell & Gene Therapies to the Clinic

Dominic Clarke, PhD

How to circumvent common barriers to bringing cell and gene therapies to the clinic

Illustration of microscopic diagnosis of bacterial vaginosis.

Novel “Chip” Could Solve Vaginal Health Crises

Swathi Kodaikal, MSc

A near-perfect organ-on-a-chip model may advance new treatment options for vaginal diseases

Photograph of gloved hands removing samples from storage.

Guidelines for Sample Management Processes and Data Integrity

Today's Clinical Lab

Download this white paper to learn about maintaining sample integrity and quality to achieve reproducibility

5 Assays for Testing Adoptive Cell Therapy Quality

Daniel Millard, PhD

The benefits and limitations of five popular cell viability assays

Illustration of a bag of blood held in someone’s palms being transfused into another person, with the tube forming a heart shape, representing the donor-recipient relationship for blood transfusions.

Lab-Grown Blood Given to Humans in First Trial

Zahraa Chorghay, PhD

The RESTORE clinical trial in the UK will assess the viability of manufactured blood

Photo of droplet digital PCR tubes against a black background.

Removing Roadblocks in Cell and Gene Therapy Quality Control

Marwan Alsarraj, MS

Droplet digital PCR (ddPCR) technology provides unmatched quality control for cell and gene therapies

Photo of a clinical professional wearing PPE sitting at a biological safety cabinet preparing the gene therapy.

FDA-Approved Gene Therapy for Transfusion-Dependent Beta-Thalassemia Offers Potential Cure

María Carla Rosales Gerpe, MSc, PhD

Patients with transfusion-dependent beta-thal will soon be treated with lentiviral vector gene therapy Zynteglo to restore hemoglobin levels

New CRISPR-Cas Approach Permits More Precise DNA Cleavage

Massachusetts General Hospital

So-called SpRYgests enable DNA cutting at practically any sequence for DNA editing

Using Machine Learning to Unlock the Genomic Code in Clinical Cancer Samples

University of Helsinki

This new tool could help unlock the medicinal value of millions of archived cancer samples

Aliquot of mammalian cells into the 6 well plate for cellular assay

A Breakthrough for Fast, Efficient Production of Human Immune Cells

University of British Columbia

The discovery could help make the field of immune cell therapy more broadly applicable

Computer render of cells or embryos under microscope

New Method Mass-Produces Antitumor Cells to Treat Blood Diseases and Cancer

Purdue University

New patent-pending method to mass-produce CAR-neutrophils

Safety Issues Plague Cell and Gene Therapy Trials. Single-Cell Analysis Can Help

Brittany Enzmann, PhD

Single-cell DNA and omic characterization can help avoid costly clinical holds and potential harm to patients

Photo of a clinical lab professional loading an mRNA plate into automation platform.

Automating Synthetic Biology’s Future

Rajan Kapadia

Automation is fueling the future of synthetic biology

Illustration of clinical lab professionals wearing personal protective equipment in a clinical lab.

Biocontainment at Clinical Trial Sites: The Institutional Biosafety Committee Perspective

Christopher Doyle, PhD

The most significant site-level safety concerns for trials are related to improper use of sterile compounding equipment

Photo of a clinical professional reaching into a BSC to culture cell therapies.

Solving Cell Therapy’s “Garbage in, Garbage out” Problem with Automation

Tony Ward

Despite industry’s emphasis on cell engineering and expansion, better starting materials are the foundation of the manufacturing revolution

Immunofluorescence image obtained after thawing and immunostaining human airway organoids with for DAPI (nucleic acid stain; blue), KRT5 (basal cell marker, red) and phalloidin (F-Actin, green).

Simplifying and Standardizing Organoid Cryopreservation

Zahraa Chorghay, PhD

Latest cryopreservation media are convenient, reliable, and follow regulatory guidelines