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Molecular Diagnostics

Cell-free DNA is now being applied across multiple areas of medicine, including prenatal testing, oncology, transplantation, and infectious disease.
|3 min read

What Cell-Free DNA Means for Clinical Laboratories

CAP experts share insights on the clinical utility and evolving role of cfDNA in the clinical laboratory
byGagan Mathur, MD, MBA, CPE, FCAP andPearl Audon, DO
An exterior view of the outside building of the Children's Hospital of Philadelphia.
|3 min read

Labcorp, CHOP Partner to Expand Access to Pediatric Diagnostics Nationwide

The partnership focuses on accelerating development of pediatric diagnostics across rare disease, oncology, and metabolic conditions
byMiriam Bergeret, MSc
Inflammatory breast cancer is among the most aggressive and lethal forms of breast cancer.
|2 min read

Blood-Based RNA Biomarkers Identified for Inflammatory Breast Cancer in Liquid Biopsy Study

Researchers identify RNA-based blood biomarkers for inflammatory breast cancer using TGIRT sequencing, suggesting a potential noninvasive tool for diagnosis and disease monitoring
byToday's Clinical Lab
Visual depiction of genetic factors in cardiovascular disease risk assessment.
|2 min read

Mass General Brigham Validates Polygenic Risk Score Tool for Predicting 8 Cardiovascular Conditions

New integrated polygenic risk score test, now available across the US, may help identify patients at elevated inherited risk for cardiovascular disease before traditional clinical factors emerge
byToday's Clinical Lab
Global health experts have long sought a more rapid form of point-of-care Tuberculosis testing.
|2 min read

New Portable TB Test Matches Lab Accuracy in Minutes

MiniDock MTB, a battery-powered molecular TB test, delivers accurate results in under 30 minutes without lab equipment, expanding access in low-resource settings
byUniversity of California - San Francisco
Two researchers working in a diagnostic lab with advanced testing solutions
|4 min read

Cutting-Edge Gastrointestinal Pathogen Testing Technologies for Labs

Improving efficiency and accuracy in gastrointestinal diagnostics
byApplied BioCode
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cfDNA continues to gain momentum as a transformative tool in laboratory medicine.
|2 min read

Beyond Prenatal Testing: Cell-Free DNA Expands into Transfusion and Transplant Medicine

A new CAP article highlights the growing clinical utility of cfDNA across diagnostic and monitoring applications
byMiriam Bergeret, MSc
For clinical laboratories, the development reflects a broader shift in respiratory testing toward decentralized models.
|2 min read

QuidelOrtho Acquires LEX Diagnostics, Expands Ultra-Fast PCR Platform

QuidelOrtho has acquired LEX Diagnostics, adding a CLIA-waived multiplex RT-PCR system delivering respiratory results in less than 10 minutes
byToday's Clinical Lab
While PCR remains the dominant method in clinical molecular diagnostics, demand continues to grow for faster and more flexible workflows that can reduce time to result and expand testing outside centralized laboratories.
|1 min read

Engineered PCR and Isothermal Enzymes Aim to Accelerate Molecular Diagnostics Workflows

Watchmaker Genomics launches new PCR and RPA enzyme systems designed to improve speed and performance in molecular diagnostics
byToday's Clinical Lab
The collaboration also reflects growing interest in ctDNA-based assays as tools for more precise disease monitoring and personalized treatment strategies.
|2 min read

Quest Expands Haystack MRD ctDNA Testing in City of Hope Cancer Trials

A multi-site study will evaluate how a ctDNA assay may support residual disease detection and treatment monitoring in solid tumors
byToday's Clinical Lab
A major focus of the latest update is a restructuring of head and neck cancer protocols.
|2 min read

CAP Updates Cancer Protocols, Clarifies MMR/MSI Testing Discordance in New Article

The updates underscore shifts toward more standardized cancer reporting and more integrated interpretation of MMR/MSI testing in clinical decision-making
byMiriam Bergeret, MSc
To best manage cancer patients, diagnostics need to shift from isolated snapshots to a more continuous, longitudinal view of disease biology.
|2 min read

Beyond Snapshots: How AI Is Redefining Cancer Diagnosis and Treatment

AI positions the clinical laboratory as both a diagnostic endpoint and a partner in patient care
byPhillip G. Febbo, MD
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Bridging Vision and Execution: A Candid Conversation on the Future of the Laboratory

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Ensuring Compliance: How to Get AI Diagnostic Tools Approved for Clinical Practice

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Cutting-Edge Gastrointestinal Pathogen Testing Technologies for Labs

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The Path to Absolute Quantification in Gene Expression

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