Hematology, Hemostasis, & Urinalysis

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FDA Expands Casgevy Gene Therapy to Children 2+ with Sickle Cell Disease and β Thalassemia

FDA approval extends CRISPR-based Casgevy to pediatric patients aged 2 and older, broadening access for sickle cell disease and transfusion-dependent β thalassemia.
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Labcorp Launches FDA-Cleared 10-Minute Rapid Fentanyl Urine Test

New point-of-care test detects fentanyl metabolite norfentanyl, extending detection up to 48 hours to support faster clinical decisions in acute care settings
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CAP Updates Cancer Protocols, Clarifies MMR/MSI Testing Discordance in New Article

The updates underscore shifts toward more standardized cancer reporting and more integrated interpretation of MMR/MSI testing in clinical decision-making
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ASH Releases Guidelines for Severe Acquired Aplastic Anemia Diagnosis and Management

Recommendations outline best practices for diagnosing and managing the rare and life-threatening condition in children and adults
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Body’s Immune Response May Keep HIV in Check Without Medication

Study finds antibodies and T cells can suppress HIV in some patients without lifelong medication, opening the door to new treatment strategies
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Gut Microbiome Connected with Heart Disease Precursor

Using metagenomic sequencing, a new study reports a gut microbiome signature associated with dyslipidemia
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Direct-to-Consumer Gut Microbiome Testing Kit Results Vary Between Kits and Manufacturers

The accuracy of gut health tests remains uncertain and no study has systematically evaluated their performance until now
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Blood Test Predicts Which Bladder Cancer Patients May Safely Skip Surgery

Positive results from the RETAIN-2 trial demonstrate that a response-adapted bladder-preservation approach involving neoadjuvant chemoimmunotherapy can be considered in select patients
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Move Past the Limitations of Synthetic Reference Standards in Cancer Research

A review of cell line-derived reference standards for the investigation and molecular profiling of myeloid malignancies
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Improving the Diagnosis and Assessment of Castleman Disease

New efforts aim to overcome diagnostic and histologic challenges in Castleman disease
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Rethinking UTI Diagnostics: Getting to the Right Therapy the First Time

Urine cultures remain essential, but molecular diagnostics are narrowing the gap between testing and treatment for urinary tract infections
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New Mechanism Links Epstein-Barr Virus to Multiple Sclerosis

Exactly how Epstein-Barr virus contributes to MS has long been unclear
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A Simple Blood Test Can Predict Crohn’s Disease Years Before Symptoms Appear

Researchers have shown that a blood test that can predict Crohn’s disease years before symptoms appear, opening the doors to early diagnosis and potentially prevention
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