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Genomics, Proteomics, & Metabolomics

The study modeled the use of mNGS testing that detects both RNA and DNA pathogens within a 48-hour turnaround time compared to conventional clinical workups.
|2 min read

Earlier Use of Metagenomic Sequencing May Streamline Meningitis, Encephalitis Workups

Modeling data suggests early metagenomic sequencing could reduce unnecessary testing and shorten time to diagnosis for CNS infections
byDelve Bio
BioPathNet is an AI method for analyzing such biomedical knowledge graphs.
|3 min read

New AI Method Analyzes Biomedical Knowledge Graphs to Reveal Diagnostic Targets

The BioPathNet platform scans biomedical data networks to generate testable hypotheses that could support biomarker discovery and diagnostic development
byHelmholtz Zentrum München
Type 2 diabetes (T2D) is a growing health concern in sub-Saharan Africa, but it is often underdiagnosed or misdiagnosed.
|2 min read

Mapping Proteins in African Genomes Reveals New Paths to Fight Type 2 Diabetes

The research could help develop representative biomarkers and treatment strategies—bringing more precise and effective health care to millions of people
byHelmholtz Zentrum München
Pangenomics, a subset of bioinformatics, is the study of many different genomes from one specific species.
|3 min read

Compressive Pangenomics Breakthrough Enables Analysis of Millions of Genomes

UC engineers introduce PanMAN, a data structure that compresses and encodes large-scale genomic variation and evolutionary history, transforming microbial and human genome studies
byUniversity of California - San Diego
The consortium includes data from more than 35,000 biofluid samples, leading to approximately 250 million unique protein measurements.
|5 min read

Global Neurodegeneration Proteomics Atlas Reveals Key Disease Signatures

A global harmonized proteomics dataset of Alzheimer’s, Parkinson’s, and FTD uncovers disease signatures to accelerate diagnostics and therapeutic discovery
byZahraa Chorghay, PhD
Quagliata sat down with Today’s Clinical Lab at the Association for Molecular Pathology’s annual meeting in November.
|5 min read

Molecular Pathology Will Lean Further into Liquid Biopsy and Proteomics in 2026

Thermo Fisher’s Luca Quagliata also discusses pathologists’ desire for rapid turnaround times
byScott Wallask, BA andLuca Quagliata, PhD, BCMAS, COA
MOBILion’s strategy is to integrate its HRIM technology across the mass spectrometry ecosystem, extending beyond proteomics into metabolomics, lipidomics, exposomics, and other high-value analytical markets.
|2 min read

MOBILion Systems Reports Proof-of-Concept Data Supporting a New Proteomics Approach

Peer-reviewed and collaborator studies indicate high-resolution ion mobility may address longstanding ion utilization limits in LC-MS proteomics workflows
byMOBILion Systems, Inc.
The left panel depicts a potential-like landscape, where white streamlines represent the inferred trajectory of cell states across time. Although single-cell RNA sequencing captures only static snapshots of cells, ddHodge reconstructs the patch-worked dynamical structure by connecting many local “nows” into a coherent global picture. The right panel shows a graph-based representation of high-dimensional cell states, on which local geometry is preserved to quantify key dynamical properties such as stability, divergence, and rotational components.
|3 min read

A New Way to Map How Cells Choose Their Fate

Researchers present an innovative computational method based on modern mathematics to shed light on cell state dynamics and development
byKyushu University
Here’s a quick roundup of the stories that captured the most attention in 2025.
|2 min read

TLDR; Our Top Stories of 2025

From regulatory shifts to breakthrough diagnostics, the stories that defined clinical labs in 2025
byToday's Clinical Lab
Assistant professor Benoit Malleret (left) and Dr. Hang Jing Wen (right) examining blood smears from Plasmodium coatneyi in the laboratory.
|3 min read

Researchers Identify Potential Therapy and Diagnostic Markers for Cerebral Malaria

The study identified a nine-gene blood signature that consistently separated cerebral malaria from milder malaria and from healthy individuals
byNational University of Singapore
Instead of relying solely on clinical endpoints over extended treatment periods, the research examined whether molecular signals could reveal pharmacodynamic activity within the first few days of treatment.
|2 min read

Rapid Transcriptomics Brings Actionable Data to Early-Phase Topical Trials

Early transcriptomic readouts reveal pharmacodynamic activity in skin within days—a shift toward earlier molecular decision-making
byStéphanie Légaré, PhD
Current genetic analysis tools can estimate whether a mutation is harmful, but they cannot determine the type of disease it might cause.
|3 min read

New AI Tool Identifies Not Just Genetic Mutations, but the Diseases They May Cause

The method, called V2P, uses advanced machine learning to link genetic variants with their likely phenotypic outcomes
byMount Sinai School of Medicine andMount Sinai Hospital
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