Home
Clinical Focus
Therapeutics

Therapeutics

Illustration of the number “2024” in big bold white letters against a teal background with the word “cancer” repeated many times in faded white letters.

A Year of Advancement: AACR Cancer Progress Report 2024

Michael Schubert, PhD

Screening successes, emerging technologies, precision treatments, and other steps forward from the AACR Cancer Progress Report 2024

Photo of clinical laboratory professional wearing PPE and pipetting biomarker samples at a laboratory bench.

Supporting Biomarker-Driven Clinical Trials Through a Future-Ready Lab

Deborah Phippard, PhD

Steps that buttress biomarker analysis include laboratories adopting platform-agnostic technologies

Illustration of white puzzle pieces arranged in the shape of a human head with pieces in the middle of the brain area missing and scattered across a blue background.

Targeted Treatment Breakthrough for Aggressive Childhood Brain Cancer

Today's Clinical Lab

New research identifies a critical genetic variation in Group 3 medulloblastomas, paving the way for improved diagnostic and treatment strategies for this challenging form of pediatric brain cancer

Illustration of several yellow padlocks clustered together.

Enhancing the Precision of CRISPR-Based Gene Editing

Today's Clinical Lab

A new interdisciplinary project at Lehigh University aims to leverage AI and advanced modeling to refine CRISPR gene editing, enhancing safety and expanding its medical applications

Illustration and abstract photo of the gloved hands of a clinical researcher pipetting and culturing cells derived from patients to create patient-derived xenograft models.

Capturing the Complexity of Real Cancer Cases with Patient-Derived Xenograft Models

Michael J. Wick, PhD

Patient-derived xenograft models enable researchers to explore novel therapies and diagnostic tools within the context of specific mutational signatures, treatment histories, and more

Photo of several different blister packs of different-colored medications.

Enterprise Therapeutics Granted ‘Rare Pediatric Disease Designation’ in the US for Novel Cystic Fibrosis Investigational Therapy ETD001

Enterprise Therapeutics

ETD001 commenced Phase 2 clinical trials in July 2024, expected to complete in 2025

Photo of a Black woman in the background holding up a pink ribbon to represent breast cancer awareness.

Fibrosis Identified as a Prognostic Indicator in the Most Common Breast Cancer, Paving the Way for Antifibrotic Drug Treatments

Spanish National Cancer Research Centre

For the first time, researchers have shown that the presence of fibrosis in HER2-negative breast tumors is associated with an adverse prognosis

Pancreas cancer harbors cells in different states, with classical cells (red) and basal cells (turquoise) co-existing within individual tumors. Basal cells, which typically are associated with aggressive disease, show increased sensitivity to KRAS inhibitors, a promising new drug class for pancreatic cancer.

New Research Suggests How to Improve Effectiveness of KRAS Inhibitors in Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

New research in mouse models has uncovered a new mechanism of resistance to KRAS inhibitors

Illustration of a transparent molecular structure against a blue background representing the chemical technique bioconjugation.

What is Bioconjugation? Overview, Applications & More

LifeSynth Solutions

Explore the fundamentals of bioconjugation, including the most popular methods and techniques, as well as examples of commercial applications

Image of the brain with machine learning algorithms

NIH Researchers Develop Machine-Learning Model to Predict How Cancer Patients Will Respond to Immunotherapy

National Institutes of Health

Algorithm analyzes five common clinical characteristics from patients plus tumor mutational burden

Orange vial with "Aptima Multitest Swab Transport Media (STM)" written in black lettering with grey background.

Improve STI Outcomes and Reduce AMR with RNA Multi-Testing

Hologic

Better testing for M. gen reduces rates of undiagnosed illness and AMR likelihood

Photo of a laboratory scientist at a lab bench wearing PPE pipetting into a tube to conduct an antibody test.

FDA Approves Labcorp Cell-Based CDx for Hemophilia Gene Therapy, BEQVEZ

LabCorp

The companion diagnostic will help bring clarity to hemophilia B patients considering BEQVEZ as a treatment option

Photo of a clinician holding up a MRI digital x-ray of the human brain tumor in front of a oncology lab window.

Genetically Engineering a Treatment for Incurable Brain Tumors

Purdue University

Researchers develop fully off-the-shelf, stem cell-derived natural killer cells against glioblastoma

Photo of a stethoscope resting on top of a pile of medical records in a clinician’s office.

American College of Physicians Issues Clinical Recommendations for Newer Pharmacological Treatments of Type 2 Diabetes

American College of Physicians

The updated guideline recommends adding an SGLT-2 inhibitor or GLP-1 agonist to metformin

A 3D illustration of sickle-shaped red blood cells in the bloodstream seen in sickle cell disease.

New Drug Controls Sickle Cell Disease-Linked Hypertension

University of Maryland School of Medicine

Treatment for lung condition could help patients with SCD control complications from hypertension and kidney damage

A graphic illustration of two female researchers in PPE working in a lab with vectors of DNA structure and its packaging in the background.

Elevating Cancer Diagnostics and Treatment Using Epigenetics

Moshe Szyf, PhD

Integrating epigenetic insights into cancer research could help deliver personalized, high-quality, and cost-effective patient care

A female clinician holds a pink ribbon in front of the lens symbolizing breast cancer awareness.

Selective PARP Inhibitor Improves Survival in Breast Cancer Trial

American Association for Cancer Research

Saruparib has higher selectivity for PARP1, improving safety and tolerability compared to existing first-gen PARP inhibitors

A vector illustration of clinicians, holding a magnifying lens and a syringe, examining the human kidneys with a bottle of drugs, tablets, and test tubes in the background.

Organoids Help Uncover the Genetics of Kidney Disease

National Institutes of Health

Innovative disease modeling and gene editing techniques begin to answer long-standing questions

Two female researchers in PPE work on digital tablet and touch-screen computer interface in a lab setting.

The State of Clinical Development in 2023

Gen Li, PhD, MBA

Increasing Phase 2 clinical trial cancellations can have a long-drawn and multifold impact on clinical research

An abstract 3D illustration of bands of various DNA sequences and/or regions.

Labcorp Accelerates Molecular Residual Disease Research

LabCorp

The Plasma Detect™ is the first clinically validated, whole-genome sequencing MRD solution for early-stage colon cancer