Therapeutics Articles

Pancreas cancer harbors cells in different states, with classical cells (red) and basal cells (turquoise) co-existing within individual tumors. Basal cells, which typically are associated with aggressive disease, show increased sensitivity to KRAS inhibitors, a promising new drug class for pancreatic cancer.

New Research Suggests How to Improve Effectiveness of KRAS Inhibitors in Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

New research in mouse models has uncovered a new mechanism of resistance to KRAS inhibitors

Illustration of a transparent molecular structure against a blue background representing the chemical technique bioconjugation.

What is Bioconjugation? Overview, Applications & More

LifeSynth Solutions

Explore the fundamentals of bioconjugation, including the most popular methods and techniques, as well as examples of commercial applications

Image of the brain with machine learning algorithms

NIH Researchers Develop Machine-Learning Model to Predict How Cancer Patients Will Respond to Immunotherapy

National Institutes of Health

Algorithm analyzes five common clinical characteristics from patients plus tumor mutational burden

Orange vial with "Aptima Multitest Swab Transport Media (STM)" written in black lettering with grey background.

Improve STI Outcomes and Reduce AMR with RNA Multi-Testing

Hologic

Better testing for M. gen reduces rates of undiagnosed illness and AMR likelihood

Photo of a laboratory scientist at a lab bench wearing PPE pipetting into a tube to conduct an antibody test.

FDA Approves Labcorp Cell-Based CDx for Hemophilia Gene Therapy, BEQVEZ

LabCorp

The companion diagnostic will help bring clarity to hemophilia B patients considering BEQVEZ as a treatment option

Photo of a clinician holding up a MRI digital x-ray of the human brain tumor in front of a oncology lab window.

Genetically Engineering a Treatment for Incurable Brain Tumors

Purdue University

Researchers develop fully off-the-shelf, stem cell-derived natural killer cells against glioblastoma

Photo of a stethoscope resting on top of a pile of medical records in a clinician’s office.

American College of Physicians Issues Clinical Recommendations for Newer Pharmacological Treatments of Type 2 Diabetes

American College of Physicians

The updated guideline recommends adding an SGLT-2 inhibitor or GLP-1 agonist to metformin

A 3D illustration of sickle-shaped red blood cells in the bloodstream seen in sickle cell disease.

New Drug Controls Sickle Cell Disease-Linked Hypertension

University of Maryland School of Medicine

Treatment for lung condition could help patients with SCD control complications from hypertension and kidney damage

A graphic illustration of two female researchers in PPE working in a lab with vectors of DNA structure and its packaging in the background.

Elevating Cancer Diagnostics and Treatment Using Epigenetics

Moshe Szyf, PhD

Integrating epigenetic insights into cancer research could help deliver personalized, high-quality, and cost-effective patient care

A female clinician holds a pink ribbon in front of the lens symbolizing breast cancer awareness.

Selective PARP Inhibitor Improves Survival in Breast Cancer Trial

American Association for Cancer Research

Saruparib has higher selectivity for PARP1, improving safety and tolerability compared to existing first-gen PARP inhibitors

A vector illustration of clinicians, holding a magnifying lens and a syringe, examining the human kidneys with a bottle of drugs, tablets, and test tubes in the background.

Organoids Help Uncover the Genetics of Kidney Disease

National Institutes of Health

Innovative disease modeling and gene editing techniques begin to answer long-standing questions

Two female researchers in PPE work on digital tablet and touch-screen computer interface in a lab setting.

The State of Clinical Development in 2023

Gen Li, PhD, MBA

Increasing Phase 2 clinical trial cancellations can have a long-drawn and multifold impact on clinical research

An abstract 3D illustration of bands of various DNA sequences and/or regions.

Labcorp Accelerates Molecular Residual Disease Research

LabCorp

The Plasma Detect™ is the first clinically validated, whole-genome sequencing MRD solution for early-stage colon cancer

A vector illustration of a male researcher holding a magnifying lens at a capsule as drugs of various sizes and shapes are lined up on a belt on either side.

FDA Approves New Antibiotic for Multiple Bacterial Infections

U.S. Food and Drug Administration

The FDA granted the approval of Zevtera® to Basilea Pharmaceutica International Ltd.

3D illustration of an artery carrying red blood cells.

New Drug Slows Rare, Debilitating Genetic Disease in Trials

National Institutes of Health

The NIH-supported clinical trial could lead to the first effective treatment for ACDC disease

A person holds a model of the human pancreas between two palms horizontally.

Personalizing Enzyme Therapy to Improve Pancreatitis in Kids

Ochsner Health

When on pancreatic enzyme replacement therapy, the mean acute pancreatitis annual incidence rate decreased from 3.14 to 0.71

A female researcher works on a large instrument as she holds a sample tube with a gloved left hand.

How Automation Is Transforming Clinical Research Operations

Colin Weller, BSc/BA

Automation, AI, and digital health technologies can help make clinical trials more efficient, inclusive, and impactful

A young boy in a wheelchair looks back into the camera.

FDA Approves First Nonsteroidal Drug for DMD

U.S. Food and Drug Administration

The FDA granted the approval of Duvyzat™ to Italfarmaco S.p.A

3D illustration of a nerve cell with myelinated axons and dendrites.

Gene Therapy Improves Rare Neurodegenerative Disease in Trial

National Institutes of Health

Treatment for giant axonal neuropathy was well tolerated and slowed loss of motor function

An elder woman in a wheelchair with Parkinson's smiles at a cheerful personal care worker who's crouching over the wheelchair, resting her hands on the elder woman.

Screening for Skin-Based Biomarker Helps Diagnose Parkinson’s

Beth Israel Deaconess Medical Center

Simple test detects the key biomarker in neurodegenerative diseases that could lead to earlier diagnosis and accelerate drug development