Therapeutics Articles | Today's Clinical Lab

More than 20,000 Americans are diagnosed with AML each year, making it one of the most common types of leukemia—and one of the most aggressive.

Researchers Find Breast Cancer Drug Boosts Leukemia Treatment

Oregon Health & Science University

OHSU researchers identified new drug combination that could overcome treatment resistance in acute myeloid leukemia

The use of glucagon-like peptide-1 receptor agonists—or GLP-1RAs—has increased dramatically.

Weight Gain and Pregnancy Complications Rise After GLP-1 Discontinuation

Mass General Brigham

Discontinuing GLP-1 drugs early in pregnancy may raise risks of weight gain, diabetes, hypertension, and preterm delivery

To get the mRNA safely into the patient’s body, the researchers packaged it inside lipid nanoparticles—tiny fat-based bubbles commonly used in mRNA vaccines.

Experimental mRNA Therapy Shows Potential to Combat Antibiotic-Resistant Infections

Mount Sinai School of Medicine, Mount Sinai Hospital

Preclinical studies show mRNA therapy slows antibiotic-resistant bacteria and enhances immune response

Our findings suggest that mRNA vaccines may provide just the spark the immune system needs to turn “cold” tumors “hot.”

COVID-19 mRNA Vaccines Could Unlock the Next Revolution in Cancer Treatment—New Research

Christiano Marconi, Adam Grippin, MD, PhD

With a little help, your immune cells can be potent tumor killers

A growing number of T cell therapies, including CAR-T interventions are personalized treatments that genetically modify a patient's T cells to target and destroy cancer cells.

Epigenetic Reprogramming Safely Modifies Multiple Genes in T Cells Simultaneously for CAR-T Therapies

Arc Institute

Epigenetic editors create enhanced T cells that show improved survival in cancer models, without the risk of DNA damage

Elias Sayour (right) and lab members review research data.

Study Finds COVID-19 mRNA Vaccine Sparks Immune Response to Fight Cancer

University of Florida

Building on previous research, the observation also marks a significant step toward a long-awaited universal cancer vaccine

Globally, an estimated 1.5 million men are diagnosed with prostate cancer each year.

New Drug Combination Offers Hope for Men with Advanced Prostate Cancer

University College London

A new drug combination could significantly delay the progression of a life-threatening form of prostate cancer in men with specific genetic mutations

A single error in the genetic code of the ACTA2 gene, which encodes the smooth muscle actin protein, is the most common cause of MSMDS.

Customized Gene-Editing Technology Shows Potential to Treat Lethal Pediatric Disease

Mass General Brigham

In preclinical models, the CRISPR-Cas9 gene therapy precisely repaired the genetic error that causes a rare vascular disease

Despite recent advances in immunotherapy and targeted therapies, many patients with metastatic renal cell carcinoma, an aggressive and often fatal form of kidney cancer, either fail to respond or eventually relapse.

UCLA Researchers Develop Off-the-Shelf Immunotherapy for Metastatic Kidney Cancer

University of California - Los Angeles

Approach offers a promising next-generation strategy for treating metastatic renal cell carcinoma

Participants in both studies reported clinically meaningful improvements in overall quality of life, including physical, social/family, functional, and emotional well-being.

Gene Therapy Leads to Improved Quality of Life in Patients with Sickle Cell Disease and Beta Thalassemia

American Society of Hematology

Substantial improvements seen across ages in overall health and well-being

HIV Virus Creative artwork featuring colorized 3D prints of HIV virus particles. The virus surface (red) is covered with proteins (dark blue) that enable the virus to enter and infect human cells, and additional proteins (teal spheres) that disguise the virus from the immune system. A colorized transmission micrograph of an H9 T cell (blue) appears in the background. Note: proteins not to scale.

New Monthly Pill Shows Potential as Pre-Exposure Prophylaxis HIV Drug Candidate

PLOS

The compound, MK-8527, belongs to a novel class of antiretrovirals

The younger patients, especially those between the ages of five and eight, responded best to the treatment.

Gene Therapy Restored Hearing in Deaf Patients

Karolinska Institutet

New gene therapy well-tolerated and improves hearing in all 10 patients with congenital deafness or severe hearing impairment

Medications that block checkpoints, called immune checkpoint inhibitors, have become powerful tools for treating cancer.

Releasing a Molecular ‘Brake’ May Help Immune Cells Better Fight Cancer

Van Andel Research Institute

New findings could lead to better cancer immunotherapies by helping develop new drugs or T cell treatments to boost immune response

Leveraging the strengths of both companies, the joint research will focus on developing new methodologies to enhance the efficacy of Tregs and TILs in therapeutic applications.

Xcell Biosciences Announces Joint Research Collaboration with Thermo Fisher Scientific to Advance the Next Generation of Cell Therapies

Xcell Biosciences

Strategic collaboration to innovate Treg and TIL therapies, streamline cell therapy workflows, and enhance manufacturing efficiency

In 2025, many of the most promising trials center innovations in precision diagnostics, genetic testing, and computational modeling, especially in high-need areas like rare diseases and oncology.

Top 5 Clinical Trials Shaping Medicine in 2025

Zahraa Chorghay, PhD

From precision oncology to gene editing, these standout trials could redefine how we diagnose and treat rare diseases and cancer

Regulatory Standards and Guidance for Lab Balances

Sartorius

Strategies and standards that help clinical labs strengthen compliance, ensure weighing accuracy, and protect data integrity

Today's Clinical Lab 2025 Cancer & Precision Medicine print issue

'The Critical Role of the Clinical Lab'

Miriam Bergeret, MSc

The Today's Clinical Lab 2025 Cancer & Precision Medicine print issue features cancer screening successes, emerging technologies, and advances in targeted treatments

Illustration of an abstract retro circular burst design representing eyesight and the structure of human eye.

Gene Therapies for Retinal Diseases Head to Clinical Trials

Jennifer Welsh

Inherited retinal diseases cause vision loss and blindness. New gene therapy trials have improved sight for some

Illustration of a DNA helix molecule with DNA base pairs ready for epigenome editing.

Rewiring Biological Time and Aging with Epigenome Editing

Charles A. Gersbach, PhD

The bright, new future of therapeutic epigenome editing is already on our doorstep

Illustration of two CAR T-cells attacking a cancer cell.

Researchers Move Toward Off-the-Shelf CAR T-Cell Therapy for Cancer

Today's Clinical Lab

New breakthrough from Memorial Sloan Kettering Cancer Center shows how off-the-shelf CAR T cells from healthy donors can be modified to fight cancer without immune rejection