Molecular Diagnostics Articles | Today's Clinical Lab

New Credit Card-Sized TB Test Could Close the Diagnostic Gap in HIV Hotspots

Tulane University

Inspired a beetle's natural defense mechanism and requiring no electricity, the new field test boosts TB detection where it's needed most

A critical challenge in treating, researching, and living with multiple sclerosis is that MRI and neurological exams identify disease changes only after they have occurred.

The Future of Biomarkers in Multiple Sclerosis Care

Stephanie Buxhoeveden, PhD, MSN, FNP-BC, MSCN

MS expert Stephanie Buxhoeveden combines personal experience with scientific expertise to explore how biomarkers are transforming MS care

Homologous recombination deficiency (HRD) testing identifies tumors that are unable to effectively repair DNA damage through the homologous recombination repair pathway, which serves as a potential biomarker for predicting response to certain cancer therapies.

Association for Molecular Pathology Publishes Best Practice Recommendations for Clinical HRD Testing

Association for Molecular Pathology

Joint consensus report includes organizational representation from AMP, ASCO, ACCC, and CAP

A comprehensive understanding of reverse transcription sheds light on its dual significance in biological systems and molecular diagnostics.

How Reverse Transcription Works: From RNA to DNA Explained

Today's Clinical Lab

Reverse transcription has fundamentally reshaped molecular biology by enabling the flow of genetic information from RNA back to DNA

While gliomas are the major cause of cancer-related death in adolescents and young adults, there are distinct differences between gliomas that occur in children versus older adults, and treatment can vary depending on someone’s age at diagnosis.

Molecular Testing Unveils New Insights into Adolescent and Young Adult Brain Cancer

The Hospital for Sick Children

Specialized molecular testing helps shape potential treatments for patients with glioma

With an eye toward improving care, researchers have developed new automated lab procedures for detecting opioids in tiny amounts of blood.

New Opioid Testing Techniques Could Lead to Better Therapies

Brown University

New diagnostic tools for detecting opioids in adults and infants could help health workers more effectively treat opioid-related conditions

The LEX system supports multiplex testing for key respiratory pathogens, including Influenza A, Influenza B, and COVID-19, and is engineered to deliver PCR results in 6 to 10 minutes.

LEX Diagnostics Submits Dual Applications for FDA 510(k) Clearance and CLIA Waiver for Groundbreaking LEX VELO System

LEX Diagnostics

The VELO system is an ultrafast point-of-care molecular diagnostics platform designed to deliver highly sensitive PCR results for key respiratory pathogens directly from a swab sample in under 10 minutes

“This study shows the promise of MCED tests in detecting cancers very early, and sets the benchmark sensitivities required for their success.”

Cancers Can Be Detected in the Bloodstream 3 Years Prior to Diagnosis

Johns Hopkins Medicine

Detecting cancers years before their clinical diagnosis could help provide management with a more favorable outcome

The dismissal of CLIAC leaves a vacuum where medical lab science discussion can no longer take place, ADLM’s president says.

‘CLIAC Served as a Critical Venue’ for Lab Community, Says ADLM President

Scott Wallask, BA

Anthony Killeen reacts to news that influential committee has been dismantled by the US federal government

Photo of the main sign at the U.S. FDA Headquarters, White Oak Campus, showing buildings and trees in the background.

FDA Declines to Appeal Court Ruling on LDT Oversight

Today's Clinical Lab, Association for Molecular Pathology

AMP President Jane S. Gibson, PhD, affirms the court ruling calling it a win for patients, innovation, and molecular pathology

Photo of a clinical lab scientist wearing a white lab coat and blue gloves while analyzing samples for clinical bioinformatics in a medical laboratory.

AMP Releases Series of Reports Defining Core Bioinformatics Competencies for Clinical Diagnostic Laboratories

Association for Molecular Pathology

The three papers outline roles and required skills for bioinformaticians with respect to molecular diagnostics, clinical bioinformatics, clinical laboratory regulation, and data security

Photo of a warning sign with the image of a tick on it nailed to a tree on a forest trail.

Rethinking Lyme Disease Testing: A New Approach to Early and Accurate Detection

Jason Barker, ND

New research marks a promising step toward rethinking how we identify and manage Lyme disease and related infections in the clinical lab

Scientists have found several reliable blood-based biomarkers of Alzheimer’s disease.

USC Researchers Develop Low-Cost Blood Test for Early Alzheimer’s Detection

Keck School of Medicine of USC

In a proof-of-concept study, the test detected five key biomarkers of Alzheimer’s disease—more than current commercially available blood tests can measure

As part of an aggressive campaign to downsize and restructure HHS, the Trump administration recently eliminated this vital committee—a move that could threaten the quality of clinical laboratory tests.

ADLM Calls on HHS to Reinstate Essential Committee Needed to Ensure the Safety and Efficacy of Clinical Lab Tests

Association for Diagnostics and Laboratory Medicine

Not only will the elimination of CLIAC have a negative impact on patient care, it also isn’t likely to result in meaningful savings for the government

Photo of a clinical lab professional wearing a white lab coat and gloves in a clinical lab and loading a multiple sclerosis sample into an analyzer.

Clinically Validated Multiple Sclerosis Multi-Analyte Test Is Now Available in All 50 States

Octave Bioscience

Prior to the MSDA Test, disease management in MS relied primarily on clinical assessments and MRI

Photo showing several wood blocks with outline of human head and shoulders with one block in red, representing a positive sample of prostate cancer screening.

Seminal Fluid RNA and DNA Biomarkers Show Promise for Non-Invasive Prostate Cancer Detection

Fellow Health

First multicenter study of cell-free RNA and DNA methylation biomarkers in seminal fluid shows promise for accurate, noninvasive detection of clinically significant prostate cancer

Achieving Precision and Compliance: Best Practices for Analytical Balances

Sartorius

Minimize weighing variability with guidance on calibration, documentation, cleaning, and environmental management

Photo of blood samples in test tubes with blue caps in a clinical laboratory awaiting testing for Alzheimer's disease with VeraBIND™ Tau.

First Blood Test to Detect Alzheimer's-Related Tau Pathology

Veravas

VeraBIND™ Tau is a new noninvasive test that offers 96 percent sensitivity and 90 percent specificity, empowering earlier and more accessible Alzheimer's detection

Photo of blood test tubes stored in a tube rack on a laboratory bench awaiting next-generation sequencing for cancer research.

Integrated DNA Technologies Introduces New Hybridization Capture Solution to Accelerate Cancer Research

Integrated DNA Technologies

New xGen™ hybridization and wash offering is poised to revolutionize targeted next generation sequencing workflows

Photo of a young female cancer patient with long black hair in a health care setting shaking the hand of a healthcare provider conducting cancer screening.

2025’s Cancer Dilemma: Finding Tests That Diagnose Cancer at the Right Time

Arnon Chait, PhD, MBA

As the frequency of late-stage cancer diagnoses rises, more accurate and efficient screening methods are needed to address overspending and improve early detection outcomes