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Emerging Diagnostic Modalities & Innovation

The most value is unlocked when technology functions as part of a living ecosystem.
|3 min read

Moving Beyond the Demo: The Strategic Value of Peer Validation in Technology Selection

As advanced technology becomes central to laboratory operations, peer validation has emerged as a distinct strategic advantage
byNathan Buchbinder, BS, MBID
This technology supports minimally invasive cancer detection using a simple blood draw and a fully automated workflow.
|2 min read

A New ‘Lab-on-a-Disc’ Device Paves the Way for More Automated Liquid Biopsies

High-throughput, automated EV processing from small blood samples could streamline multiplexed liquid biopsy workflows in clinical labs
byMass General Brigham
While histologic examination and immunohistochemistry remain the foundation of cancer diagnosis, the authors explain that molecular profiling can provide critical additional insight when conventional approaches fall short.
|2 min read

CAP Highlights Molecular Testing to Clarify Difficult-to-Classify Tumors

CAP authors outline how genomic, transcriptomic, and epigenetic profiling can support pathologists when conventional histology and immunohistochemistry fall short, particularly in cancers of unknown primary
byCollege of American Pathologists
The study modeled the use of mNGS testing that detects both RNA and DNA pathogens within a 48-hour turnaround time compared to conventional clinical workups.
|2 min read

Earlier Use of Metagenomic Sequencing May Streamline Meningitis, Encephalitis Workups

Modeling data suggests early metagenomic sequencing could reduce unnecessary testing and shorten time to diagnosis for CNS infections
byDelve Bio
BioPathNet is an AI method for analyzing such biomedical knowledge graphs.
|3 min read

New AI Method Analyzes Biomedical Knowledge Graphs to Reveal Diagnostic Targets

The BioPathNet platform scans biomedical data networks to generate testable hypotheses that could support biomarker discovery and diagnostic development
byHelmholtz Zentrum München
LeapSpace uses a multi-model AI approach, selecting models based on the task to ensure optimal outcomes and flexibility as AI technologies evolve.
|3 min read

AI Meets Research: LeapSpace Goes Live with 18+ Million Articles

LeapSpace promises AI-assisted insights across 18 million full-text research papers and books, though real-world impact is yet to be measured
byElsevier
Type 2 diabetes (T2D) is a growing health concern in sub-Saharan Africa, but it is often underdiagnosed or misdiagnosed.
|2 min read

Mapping Proteins in African Genomes Reveals New Paths to Fight Type 2 Diabetes

The research could help develop representative biomarkers and treatment strategies—bringing more precise and effective health care to millions of people
byHelmholtz Zentrum München
Pangenomics, a subset of bioinformatics, is the study of many different genomes from one specific species.
|3 min read

Compressive Pangenomics Breakthrough Enables Analysis of Millions of Genomes

UC engineers introduce PanMAN, a data structure that compresses and encodes large-scale genomic variation and evolutionary history, transforming microbial and human genome studies
byUniversity of California - San Diego
Colorectal cancer is one of the most common cancers in the Western world.
|3 min read

DNA Testing of Colorectal Polyps Improves Insight into Hereditary Risks

European collaboration demonstrates the value of targeted tumor analysis
byRadboud University Medical Center
The consortium includes data from more than 35,000 biofluid samples, leading to approximately 250 million unique protein measurements.
|5 min read

Global Neurodegeneration Proteomics Atlas Reveals Key Disease Signatures

A global harmonized proteomics dataset of Alzheimer’s, Parkinson’s, and FTD uncovers disease signatures to accelerate diagnostics and therapeutic discovery
byZahraa Chorghay, PhD
Quagliata sat down with Today’s Clinical Lab at the Association for Molecular Pathology’s annual meeting in November.
|5 min read

Molecular Pathology Will Lean Further into Liquid Biopsy and Proteomics in 2026

Thermo Fisher’s Luca Quagliata also discusses pathologists’ desire for rapid turnaround times
byScott Wallask andLuca Quagliata, PhD, BCMAS, COA
MOBILion’s strategy is to integrate its HRIM technology across the mass spectrometry ecosystem, extending beyond proteomics into metabolomics, lipidomics, exposomics, and other high-value analytical markets.
|2 min read

MOBILion Systems Reports Proof-of-Concept Data Supporting a New Proteomics Approach

Peer-reviewed and collaborator studies indicate high-resolution ion mobility may address longstanding ion utilization limits in LC-MS proteomics workflows
byMOBILion Systems, Inc.
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