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Emerging Diagnostic Modalities & Innovation

Photo of a clinical laboratory scientist looking at a tissue biopsy scan on a computer monitor.
|3 min read

New Compact Imaging Device Enables Rapid, Label-Free Cancer Tissue Analysis Without Staining

A miniaturized metasurface-based system captures full tissue imaging data in a single acquisition, supporting faster, stain-free analysis and future portable diagnostic workflows
byToday's Clinical Lab
MethylScan blood test support for clinical labs
|2 min read

UCLA Researchers Unveil A High-Sensitivity, $20 Liquid Biopsy for Multi-Disease Early Detection

Researchers at UCLA have developed MethylScan, a low-cost liquid biopsy that detects multiple cancers and liver diseases using DNA methylation
byJanette Wider
Dr. Damian Young, investigator at Texas Children’s Duncan Neurological Research Institute (Duncan NRI) and director of the Center for Drug Discovery at Baylor College of Medicine, along with collaborators has been awarded a $6.7 million grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to develop new approaches to rapidly identify potential treatments for Alzheimer’s disease and related dementias with the goal of accelerating the discovery of new therapies.
|3 min read

Texas Children’s Launches Large-Scale Open Drug Discovery Platform for Alzheimer’s Therapies

The NIH-funded initiative combines high-throughput screening and AI, giving global researchers access to one of the largest Alzheimer’s discovery datasets
byTexas Children's Hospital
cfDNA continues to gain momentum as a transformative tool in laboratory medicine.
|2 min read

Beyond Prenatal Testing: Cell-Free DNA Expands into Transfusion and Transplant Medicine

A new CAP article highlights the growing clinical utility of cfDNA across diagnostic and monitoring applications
byMiriam Bergeret, MSc
The continued evolution of clinical trials depends on their integration with comprehensive training, structured statistical planning, and effective communication.
|3 min read

Ensuring Endpoint Integrity in Complex Clinical Trials

Clarity in trial definitions and communication practices underpins reliable interpretation of complex study data
byJanet Overvelde, BSc, PMP
While PCR remains the dominant method in clinical molecular diagnostics, demand continues to grow for faster and more flexible workflows that can reduce time to result and expand testing outside centralized laboratories.
|1 min read

Engineered PCR and Isothermal Enzymes Aim to Accelerate Molecular Diagnostics Workflows

Watchmaker Genomics launches new PCR and RPA enzyme systems designed to improve speed and performance in molecular diagnostics
byToday's Clinical Lab
The collaboration also reflects growing interest in ctDNA-based assays as tools for more precise disease monitoring and personalized treatment strategies.
|2 min read

Quest Expands Haystack MRD ctDNA Testing in City of Hope Cancer Trials

A multi-site study will evaluate how a ctDNA assay may support residual disease detection and treatment monitoring in solid tumors
byToday's Clinical Lab
A major focus of the latest update is a restructuring of head and neck cancer protocols.
|2 min read

CAP Updates Cancer Protocols, Clarifies MMR/MSI Testing Discordance in New Article

The updates underscore shifts toward more standardized cancer reporting and more integrated interpretation of MMR/MSI testing in clinical decision-making
byMiriam Bergeret, MSc
To best manage cancer patients, diagnostics need to shift from isolated snapshots to a more continuous, longitudinal view of disease biology.
|2 min read

Beyond Snapshots: How AI Is Redefining Cancer Diagnosis and Treatment

AI positions the clinical laboratory as both a diagnostic endpoint and a partner in patient care
byPhillip G. Febbo, MD
The study stands out compared to similar research because the model’s results were validated across multiple independent datasets, according to the researchers.
|2 min read

New AI Model Can Detect Multiple Cognitive Brain Diseases from a Single Blood Sample

The model is built from one of the world’s largest neurodegenerative protein datasets
byLund University
The FNIH Biomarkers Consortium has been asking "what’s next" in the Alzheimer’s space for over 20 years.
|4 min read

Counting Down to Alzheimer’s Disease

FNIH’s Alessio Travaglia, PhD, discusses the new predictive “clock” model for Alzheimer’s disease
byZahraa Chorghay, PhD
The research was carried out by Carles López Mateu, María Gómez Mahiques, F. Javier Gil Terrón, Víctor Montosa i Micó, Juan M. García-Gómez and Elies Fuster García, in collaboration with researchers from Oslo University Hospital.
|2 min read

A New Biomarker Helps Assess the Aggressiveness of Glioblastoma

Developed by the ITACA BDSLab, it can identify different patterns of tumor growth and independently predict patient survival
byUniversitat Politècnica de València
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