Human brain with the amygdala highlighted in red
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Amygdala Overgrowth That Occurs in ASD May Begin during Infancy

Accelerated growth begins between six and 12 months of age

National Institutes of Health
Published:Mar 28, 2022
|2 min read

The amygdala—a brain structure enlarged in two-year-old children diagnosed with autism spectrum disorder (ASD)—begins its accelerated growth between six and 12 months of age, suggests a study funded by the National Institutes of Health. The amygdala is involved in processing emotions, such as interpreting facial expressions or feeling afraid when exposed to a threat. The findings indicate that therapies to reduce the symptoms of ASD might have the greatest chance of success if they begin in the first year of life, before the amygdala begins its accelerated growth.

The study included 408 infants, 270 of whom were at higher likelihood of ASD because they had an older sibling with ASD, 109 typically developing infants, and 29 infants with Fragile X syndrome, an inherited form of developmental and intellectual disability. The researchers conducted MRI scans of the children at six, 12, and 24 months of age. They found that the 58 infants who went on to develop ASD had a normal-sized amygdala at six months, but an enlarged amygdala at 12 months and 24 months. Moreover, the faster the rate of amygdala overgrowth, the greater the severity of ASD symptoms at 24 months. The infants with Fragile X syndrome had a distinct pattern of brain growth. They had no differences in amygdala growth but enlargement of another brain structure, the caudate, which was linked to increased repetitive behaviors.

The research team, part of the NIH Autism Centers of Excellence Infant Brain Imaging Study network, was led by Mark Shen, PhD, of the University of North Carolina at Chapel Hill and the Infant Brain Imaging Study. The study appears in the American Journal of Psychiatry. Funding was provided by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences and National Institute of Mental Health.

The authors suggested that difficulty processing sensory information during infancy may stress the amygdala, leading to its overgrowth.

- This press release was originally published on the National Institutes of Health website